Abacavir=ABC, uses and effect

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Trade names: (Abec, Abamune, Ziagnen)

 

Function (Antiretroviral Drugs)
It is a drugs produce to treat HIV-1 and HIV-2 infection. It work by reversing the nucleoside, at such inhibit the transcription of nucleotide in the body system of HIV patient.

Usage

For treating either HIV-1 or HIV-2 infection, it should be used in combination with other antiretroviral drugs.

Availability

300mg tablet
20mg/ml oral solution come with oral dosing syringe

Prescription

Children less than 25kg: should be given 16mg/kg/day in 2 divided dose, without exceeding 600mg/day.
Children 25kg and above with adult: should be given 600mg/day in 2 divided dose.

Prescription table

weight
20mg/ml oral solution
300mg tablet
3 to 5kg
3ml x 2
Nil
6 to 9kg
4ml x 2
Nil
10 to 13kg
Nil
Nil
14 to 19kg
Nil
½ tablet x 2
20 to 24kg
Nil
1 tablet am and ½ tablet pm
25kg above
Nil
1 tablet x 2
Duration of administration; it base on the affectivity of the drugs and they the patient tolerate the drugs.

Precautions

Do not administer to patient with history of severe  intolerance to the drugs which lead to previous discontinuous use of the drugs.
Stop the medication when the following sign and symptom occur;
1.      Lactic acid with hepatic disorder
2.      Myalgia
3.       renal impairment
4.      Skin rash
5.      Nausea
6.      Vomiting
7.      Abdominal pain
8.      Diarrhea
9.      Cough
10.  Dyspsonea
11.  Headache
12.  Oedema
13.  Lethargy
14.  Malaise
15.  Arthralgia
16.  Hypotension
17.  Lymphadenopathy
18.  Avoid taking it during pregnancy, can only be taken with proper monitoring when there are no availability of other antiretroviral drugs.
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Usage Advice

When half of the tablet is required, use a tablet cutter, or cutter to cut the tablet into two equal pieces

Storage; store bellow 30ºC

 

Once open, oral solution when keep at temperature bellow 30ºC, it can be store for a maximum of 2 months
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