Drug Distribution

Drug distribution is the process whereby drugs taken into the body system reversibly leaves the blood vessels and enters the interstitium (extracellular fluid) and the tissues. For drugs administered intravenous (IV), absorption is not a problem, and the primary phase (from immediately after administration via the rapid fall in concentration) represents the distribution phase, during which the drug rapidly leaves the circulation and enters the tissues on this picture.

Drugs distribution 1

The distribution of a drug from the plasma to the interstitium relies followings;

  1. Cardiac output and local blood flow
  2. Capillary permeability
  3. The tissue volume
  4. The ability on how the drugs bind to plasma and tissue proteins
  5. The relative lipophilicity of the drug.

Be the first to comment

Leave a Reply

Your email address will not be published.